Publicaciones
"Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Anti-parasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion”
Fueyo González, F. J.; Ebiloma, G. U.; Izquierdo García, C.; Bruggeman, V.; Sánchez Villamañán, J. M.; Donachie, A.; Balogun, E. O.; Inaoka, D. K.; Shiba, T.; Harada, S.; Kita, K.; de Koning, H. P.; Dardonville, C.
J. Med. Chem. 2017, doi:10.1021/acs.jmedchem.6b01740.
"Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei"
Alkhaldi, A.A.M.; Martinek, J.; Panicucci, B.; Dardonville, C.; Zíková, A.; de Koning, H.P.
Int. J. Parasitol.-Drugs Drug Resist., 2015, 6, 23-34.
doi:10.1016/j.ijpddr.2015.12.002
"Bisimidazoline arylamides binding to the DNA minor groove. N1-hydroxylation enhances binding affinity and selectivity to AATT sites"
Ríos Martínez, C.H. Lagartera, L., Trujillo, C., Dardonville, C.
MedChemComm, 2015, 6, 2036-2042.
http://dx.doi.org/10.1039/C5MD00292C
"Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro.
Ríos Martínez, C.H.; Nué Martínez, J.J.; Ebiloma, G.U.; de Koning, H.P.; Alkorta, I.; Dardonville, C.
Eur. J. Med. Chem. 2015, 101, 806-817.
http://dx.doi.org/10.1016/j.ejmech.2015.07.013
http://authors.elsevier.com/a/1RRrgoqiPn9rI (link to the free pdf, valid until September 17, 2015)
"Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells"
Ramos.Molina, B.; López-Contreras, A.J.; Lambertos, A.; Dardonville, C.; Cremades, A.; Penafiel, R.
Amino Acids 2015, DOI: 10.1007/s00726-015-1931-3
http://link.springer.com/article/10.1007%2Fs00726-015-1931-3
"Antiprotozoal activity and DNA binding of dicationic acridones"
Montalvo-Quirós, S.; Taladriz-Sender, A.; Kaiser, M.; Dardonville, C.
J. Med. Chem. 2015, 58, 1940-1949.
http://pubs.acs.org/articlesonrequest/AOR-tVWZpsi4cYxkCEXvWNSD
http://hdl.handle.net/10261/98250
"Observation of diastereotopic signals in 15N NMR spectroscopy"
Alkorta, I.; Dardonville, C.; Elguero, J.
Angew. Chem. Int. Ed. 2015, DOI: 10.1002/anie.201412144
http://onlinelibrary.wiley.com/doi/10.1002/anie.201412144/abstract
"A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines."
Ríos Martínez C.H., Miller F., Ganeshamoorthy K., Glacial F., Kaiser M., de Koning H.P., Eze A.A., Lagartera L., Herraiz T., Dardonville C.
Antimicrob. Agents Chemother. 2015, 59, 890-904.
http://aac.asm.org/content/early/2014/11/18/AAC.03958-14
http://hdl.handle.net/10261/122423
"SAR studies of diphenyl cationic trypanocides: superior activity of phosphonium over ammonium salts."
Dardonville, C.; Alkhaldi, A.; de Koning, H.
ACS Med. Chem. Lett. 2015, 6, 151–155.
http://pubs.acs.org/articlesonrequest/AOR-iYsDhw2vd883qjXT49qb
"Antiprotozoal activity and DNA binding of N-Substituted N-phenylbenzamide and 1,3-Diphenylurea Bisguanidines"
Ríos Martínez, C.H., Lagartera, L., Kaiser, M., Dardonville, C.
Eur. J. Med. Chem. 2014, 81, 481–491.
http://dx.doi.org/10.1016/j.ejmech.2014.04.083
http://hdl.handle.net/10261/98250
"In and Out the minor groove: Interaction of an AT-rich DNA with the CD27 drug"
Acosta-Reyes, F. J.; Dardonville, C.; de Koning, H. P.; Natto, M.; Subirana, J. A.; Campos, J. L.
Acta Cryst. Section D 2014, D70, 1614-1621
http://journals.iucr.org/d/issues/2014/06/00/issconts.html
"Rapid Determination of Ionization Constants (pKa) by UV Spectroscopy Using 96-Well Microtiter Plates”
Ríos Martínez, C.H., Dardonville, C.
ACS Med. Chem. Lett.. 2013, 4, 142-145.
http://pubs.acs.org/articlesonrequest/AOR-TV3vU6DJ386KArNmw9jF
http://hdl.handle.net/10261/82654
“Discovery of Nitroheterocycles Active against African Trypanosomes. In Vitro Screening and Preliminary SAR Studies”
Arán, V. J., Kaiser, M., Dardonville, C.
Bioorg. Med. Chem. Lett.. 2012, 22, 4506-4516.
http://dx.doi.org/10.1016/j.bmcl.2012.06.004
http://hdl.handle.net/10261/82953
”Validation of novel fluorescence assays for the routine screening of drug susceptibilities of Trichomonas vaginalis”
Natto, M.; Savioli, F.; Quashie, N.; Dardonville, C.; Rodenko, B.; De Koning, H.
J. Antimicrob. Chemother. 2012, 67, 933-943
http://dx.doi.org/ 10.1093/jac/dkr572
http://hdl.handle.net/10261/83024
”Synthesis and Structure-Activity Analysis of New Phosphonium Salts with Potent Activity Against African Trypanosomes”
Taladriz, A.; Healy, A.;Flores Pérez, E.; Herrero García, V.; Ríos Martínez, C.; Alkhaldi, A.; Eze, A.; Kaiser, M.; De Koning, H.; Chana, A.; Dardonville, C.
J. Med. Chem. 2012, 55, 2606-2622
http://pubs.acs.org/articlesonrequest/AOR-cEyQe2Q8XwnZFvdysDXD
”Synthesis and Antiprotozoal Activity of N-Alkoxy Analogues of the Trypanocidal Lead Compound 4,4'-Bis(imidazolinylamino)diphenylamine with Improved Human Blood Brain Barrier Permeability.”
Nieto Garrido, L.; Mascaraque, A.; Miller, F.; Glacial, F.; Rios Martinez, C.; Kaiser, M.; Brun, R.; Dardonville, C.
J. Med. Chem. 2011, 54, 485-494.
http://pubs.acs.org/doi/abs/10.1021/jm101335q
http://hdl.handle.net/10261/83027
“New benzophenone-derived bisphosphonium salts as leishmaniccidal leads targeting mitochondria through inhibition of respiratory complex II”
Luque-Ortega, J. Román; Reuther, P.; Rivas, L.; Dardonville, C.
J. Med. Chem. 2010, 53, 1788-1798.
http://pubs.acs.org/articlesonrequest/AOR-SgiPpCxcBVI7NmktKXq7
http://hdl.handle.net/10261/83057
”Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives”
Dardonville, C.; Fernández-Fernández, C.; Gibbons, S-L.; Jagerovic, N.; Nieto, L.; Ryan, G.; Kaiser, M.; Brun, R.
Antimicrob. Agents Chemother. 2009, 53(9), 3815-3821.
http://aac.asm.org/cgi/reprint/53/9/3815.pdf?ijkey=zs2eGp5ygtV6r8r&keytype=finite
http://hdl.handle.net/10261/83061
"Crystal Structure of a Trypanocidal 4,4´-Bis(imidazolinylamino)diphenylamine Bound to DNA”
Glass, L.S.; Nguyen, B.; Goodwin, K.D.; Dardonville, C.; Wilson, W.D.; Long, E.C.; Georgiadis, M.M.
Biochemistry 2009, 48, 5943-5952.
http://pubs.acs.org/articlesonrequest/AOR-4Z4FB6rsWqKvRujJjSJV
http://hdl.handle.net/10261/83072
”Efficient one-pot synthesis of 1-alkoxy-2-arylaminoimidazolines from N-alkoxy-N-(2-aminoethyl)-2-nitrobenzenesulfonamides and arylisothiocyanates”
Mascaraque, A.; Nieto, L.; Dardonville, C.
Tetrahedron Lett. 2008, 49, 4571-4574
http://www.sciencedirect.com/science/article/pii/S0040403908010125
http://hdl.handle.net/10261/83075
”New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity”
Rodríguez, F.; Rozas, I.; Kaiser, M.; Brun, R.; Nguyen, B.; Wilson, W.D.; García, R.N.; Dardonville, C.
J. Med. Chem., 2008, 51, 909–923.
http://pubs.acs.org/doi/abs/10.1021/jm7013088
http://hdl.handle.net/10261/83090
”DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.”
Dardonville, C.; Barrett, M. P.; Brun, R.; Kaiser, M.; Tanious, F.; Wilson, W.D.
J. Med. Chem. 2006, 49, 3748-3752.
http://pubs.acs.org/doi/abs/10.1021/jm060295c
http://hdl.handle.net/10261/84106
”Recent advances in anti-trypanosomal chemotherapy: patent literature 2002-2004.”
Dardonville, C.
Exp. Opin. Ther. Patent. 2005, 15, 1241-1257.
http://informahealthcare.com/doi/abs/10.1517/13543776.15.9.1241
http://hdl.handle.net/10261/84144
”Bisguanidinium, bis(2-aminoimidazolinium) and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.”
Dardonville, C.; Brun, R.
J. Med. Chem. 2004, 47, 2296-2307.
http://pubs.acs.org/doi/abs/10.1021%2Fjm031024u
http://hdl.handle.net/10261/84226
